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Hot Sale! We provide high quality Poly(1-vinylpyrrolidone-co-vinyl acetate) (CAS 25086-89-9), at a very affordable prices to our customers. Good producer of 25086-89-9 in bulk supply high purity Copovidone in stock, low price, fast delivery.
Copovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches. In a formulation, traces of peroxides in copovidone can impact the stability of drug substances that are prone to oxidation. Copovidone is a highly extrudable water-soluble thermoplastic copolymer manufactured by the polymerization of 6 parts of the hydrophilic group N-vinylpyrrolidone and four parts of the lipophilic monomer vinyl acetate.
The CAS number of Poly(1-vinylpyrrolidone-co-vinyl acetate) is 25086-89-9.
More information of Poly(1-vinylpyrrolidone-co-vinyl acetate) 25086-89-9 are:
CAS Number |
25086-89-9 |
Density |
1.27 g/mL at 25 °C(lit.) |
Boiling Point |
217.6oC at 760 mmHg |
Flash Point |
72 °F |
Vapor Pressure |
0.132mmHg at 25°C |
Refractive Index |
1.4300 to 1.4380 |
HS CODE |
29349990 |
PSA |
46.61000 |
LogP |
1.38320 |
The chemical formula of Poly(1-vinylpyrrolidone-co-vinyl acetate) is (C6H9NO)n.(C4H6O2)m which containing 10 Carbon atoms,15 Hydrogen atoms,1 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight, and the molecular weight of Poly(1-vinylpyrrolidone-co-vinyl acetate) is 197.23100
The copovidone can be used separately or in combination with lactose, dicalcium phosphate (DCP), and microcrystalline cellulose (MCC) as a dry binder in the roller-compaction process to produce granules with good flow and bulk density. Copovidone has several advantages in pharmaceutical application by its attributes. Differences in the manufacturing process from different suppliers of copovidone can influence the properties of the copovidone produced.
InChI:InChI=1/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
Relevant articles related to Poly(1-vinylpyrrolidone-co-vinyl acetate):
Article |
Source |
Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser |
It was found that as copovidone absorbs at the laser’s wavelength, sintering was feasible without using an absorbance enhancer… Pharmaceutics 2021, 13(2), 160; |
NMR and thermal studies for the characterization of mass transport and phase separation in paracetamol/copovidone hot-melt extrusion formulations |
The diffusion coefficient of a model drug/polymer system (paracetamol/copovidone) was determined for different drug loadings and at temperatures relevant to the HME process… Mol. Pharmaceutics 2020, 17, 6, 2021–2033 |
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