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β-Cyclodextrin with sulfobutyl ether groups and sodium ions substituted along the length of the molecule. β-Cyclodextrin is a cyclic oligosaccharide produced from starch via enzymatic conversion. Betadex sulfobutyl ether sodium, a type of cyclodextrin, a patent applied in 2018 with remdesivir formulations with β-cyclodextrins may extend the exclusivity protection for injectable remdesivir in the USA up to 2038, as the data is shown in the US FDA Orange Book.
The CAS number of β-Cyclodextrin, sulfobutyl ethers, sodium salts is 182410-00-0.
More information of β-Cyclodextrin, sulfobutyl ethers, sodium salts 182410-00-0 are:
CAS Number |
182410-00-0 |
HS CODE |
2940006000 |
Storage and Stability | Store at 4ºC. Product is stable for 12 months after receipt. |
Melting Point | 202-204°C (lit) |
PSA |
663.21000 |
LogP |
-12.36960 |
Synonyms for β-Cyclodextrin, sulfobutyl ethers, sodium salts 182410-00-0:b-Cyclodextrin, sulfobutyl ethers,sodium salts;
The chemical formula of Betadex Sulfobutyl Ether Sodium is C42H70O35 which containing 42 Carbon atoms,70 Hydrogen atoms and 35 Oxygen atoms,and the molecular weight of β-Cyclodextrin, sulfobutyl ethers, sodium salts is 1451.29000.
β-Cyclodextrin is commonly used to produce HPLC columns allowing chiral enantiomers separation. Indeed, nirmatrelvir and one of the excipients contained in remdesivir (called betadex sulfobutyl ether sodium) are renally cleared, and accumulate in patients with abnormal kidney function. betadex sulfobutyl ether sodium has a high rate of renal excretion and can accumulate at patients with renal dysfunctions.
1. It is an important modified production of Beta-Cyclodextrin.
2. It is mainly used in the azotic medicine as an excipient.
3. It is a new type of anionic high water-soluble cyclodextrin derivatives.
Relevant articles related to β-Cyclodextrin, sulfobutyl ethers, sodium salts:
Article |
Source |
Meeting USP Specs and beyond: The case study of developing Betadex Sulfobutyl Ether Sodium T Sohajda, J Szemán, L Szente - academia |
The case study of developing Betadex Sulfobutyl Ether Sodium … Among the cyclodextrin derivatives presented in pharmacopoeias worldwide, Sulfobutyl-ether-beta-cyclodextrin … |
Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: characterization of electrospun-and lyophilized formulations Carbohydrate Polymers Volume 264, 15 July 2021, 118011 |
All these samples met the quality requirements set for pharmaceutical grade USP Betadex Sulfobutyl Ether Sodium – SBECD. The samples will be marked as source No. 1.-2.-3.-4.-5. … |
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